Chronic nonspecific musculoskeletal pain in adults with special reference to serum uric acid levels
Keywords:
Uric Acid, Chronic Musculoskeletal Pain, Adults, Hyperuricemia, HypouricemiaAbstract
Introduction: Increased serum uric acid levels have been found to be variably associated with chronic nonspecific musculoskeletal pain in different subgroups of population. Tresent study is aimed knowing association increased serum uric acid levels in adult population with chronic nonspecific musculoskeletal pain. Primary outcome measure was to know levels of serum uric acid levels in patients with chronic nonspecific musculoskeletal pain and, secondary outcome measure was to know effect of Hypouricemic agents Febuoxastat in patients with hyperuricemia. Methods: One hundred and twenty five (n=125) adult patients (M: F-63:62) having chronic nonspecific musculoskeletal pain of ≥ 6 weeks duration were included in study and, their serum uric acid levels were estimated. An eleven points (0-10) Numerical Rating Scale (NRS) was used to assess level of chronic musculoskeletal pain in study participants. Patients with hyperuricemia were given oral Hypouricemic drug febuoxastat. Study was conducted for period one year. Results: Serum uric acid levels were raised in a significant proportion (p value ˂0.0001) of patients (70.4%) with chronic nonspecific musculoskeletal pain. Mean serum uric acid level was 8.3mg/dl in 70.4% (n=88) patients and 5.6 mg/dl in 20 %( n=25) patients. Mean serum uric acid level was below 2.0mg/dl (1.85±0.10mg/dl) in the remaining 9.6% (n=12) patients. Among the 88 patients having higher mean serum uric acid levels 39.2% (n=49) were female and 31.2 %( n=39) were male patients. Conclusion: Increased serum uric acid levels have an important role in development and pathogenesis chronic non specific musculoskeletal pain in adults. Both increased and decreased serum uric acid levels can cause symptomatic chronic nonspecific musculoskeletal pain.
References
McHorney CA, Ware JE Jr, Raczek AE. Med Care. The MOS 36-item short form health survey (SF- 36):II.Psychometric and clinical tests of validity in measuring physical and mental health constructs. 1993, 31(3):247-263.
Croft P, Rigby AS, Boswell R, Schollum J, Silman A. J Rheumatol. The prevalence of chronic widespread pain in general population. 1993 Apr; 20(4):710-3.
Andersson HI, Ejlertsson G, Rosenberg C. Clin J Pain .Chronic pain in geographically defined general population: Studies of differences in age, gender social class, and pain localization. 1993; 9:174-182.
ISAP subcommittee on Taxonomy. Pain .Classification of chronic pain. 1986; (Suppl 3): S25-S214.
Potter RG, Jones JM. Br J Gen Pract .The evolution of chronic pain among patients with musculoskeletal problems: a pilot study in primary care. 1992; 42:462-64.
Ingemar H Andersson. Rheumatology International Serum uric acid predicts changes in reports of non-gouty chronic pain: a prospective study among women with inflammatory and non-inflammatory pain.. 01/2012; 32(1):193-8.
Heng Jung Hsu, Chiung-Hui Yen, kuang Hung Hsu et al. BMC Nephrology. Factors associated with chronic musculoskeletal pain in patients with chronic kidney disease. 2014, 15:6.
Andersson HI, Ejtertsson G, Rosenberg C. Scand J Rheumatol Characteristics of subjects with chronic pain in relation to local and widespread pain. 1996; 25:146-154.
Mills KR, Edwards RH. J Neurological sciences .Investigative strategies for muscle pain.1983; 58:73-88.
Issberner U, Rech RW, Steen KH. Neurosci Lett .Pain due to tissue acidosis: a mechanism for inflammatory and ischemic myalgia. 1996; 208(3):191-4.
Esinger J, Plantamura A. J A Coll Nutr Glycolysis abnormalities in Fibromyalgia. 1994; 13(2):144-148.
Aarflot T, Bruusgaard D. Scand J Rheumatol Chronic musculoskeletal complaints and subgroups with special reference to uric acid. 1994; 23:25-29.
Christopher Ekpenyong, Ernest Akpan. American Journal of Internal medicine .Abnormal serum uric acid levels in health and disease: A double edged sword.2014; 2(6):113-130.
Abdou S Ellabban, Shereen R kamel, Hany T Asklany, Lamia H Ali, et al. Egypt Rheumatol rehab Serum uric acid in patients with chronic nonspecific musculoskeletal complaints: its association with metabolic syndrome and carotid intima media thickness. 01/2011; 39(4).
Naeema Afzal,Tafazzul-e- Haque Mahmud,S Shah Jahan,Salma Kundi. J Ayub Med Coll Abbottabad .Uric acid profile in patients with chronic nonspecific musculoskeletal pain..2003 Oct-Dec; 15(4):5-9.
Srivastava DC, Gaur SC (2005). Indian Journal of orthopedics .Evaluation and assessment of symptomatic uricemia in vegetarian population. 2005; 39(2):117-120.
Hickman PF, Kemp GJ, Thompson CH. Br J cancer .A novel antineoplastic agent and protein kinase C activator induces human myalgia and muscle metabolic defects; a 31p magnetic resonance spectroscopic study. 1995; 72(4):998-1003.
HellstenY, Frandsen V, Orthenblol N. J Physiol Cond .Xanthine oxidase in human skeletal muscle following eccentric exercise: a role in inflammation 1997; 498(pt1):239-248.
Yamasaki T, Hamaguchi T, Nakajina H. Nippon Rinsho. Myogenic Hyperuricemia. 1996; 54(12):3343-8. 20. F.Salaffi, A Ciapetti, M.Carotti. Reumatismo. Pain assessment strategies in patients with musculoskeletal conditions. 2012; 64(4):216-229.
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