A prospective, randomized controlled trial of single dose of Cefepime and tazobactum as the sole prophylactic preoperative antibiotics in Laparoscopic cholecystectomies
Keywords:
Postoperative, Surgical site infections, AntibioticsAbstract
Introduction: Anti microbial prophylaxis before any elective surgery is a preferred deterrent to post operative surgical site infection now. Many regimes with different antimicrobial agents are tried and most of the institutions have developed their own regime or philosophy to address postoperative surgical site infection. Most of standard textbook of surgery suggests a single dose of Intravenous antibiotic dose, preferably tird generation cephalosporin, at appropriate time before surgery, Most preferably at induction of anaesthesia or within half hour of starting a surgery. Aim was to find out how combination of cefepime, a fourth generation cephalosporin combined with Tazobactum fare in preventing post operative SSI in laparoscopic cholecystectomies. Methods: A total of 138 patients (above 16 years) were taken for study. It was a randomized and blind study. Patients were prospectively analysed. First, patients were divided into two groups. Different antibiotics combinations were studied to understand efficacy of those prophylaxis in preventing the SSI in Laparoscopic cholecystectomies. We are reporting experience with Cefepime and tazobactum combination in this work in prevention of SSI in cases undergoing Laparoscopic Cholecystectomies in our hospital setting. Results: Keeping outcome of the study in mind all materials was analysed and statistical analysis done and confidence intervals were noted. The study revealed interesting observations. Single dose pre operative prophylaxis scored over three doses regime in all cases for lap surgery. Conclusion: Multiday and antibiotics use for a prolonged period is not advisable these days after a routine elective abdominal surgery. Single dose injection of Cefepime+ Tazobactum at incision is good enough to prevent SSI after laparoscopic cholecystectomies.
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