Colorectal cancer: clinicohistopathological study at tertiary care hospital in Western Maharashtra
Keywords:
Colon cancer, Adenocarcinoma colon, Histopathology colonAbstract
Aims and objectives: To study the clinicopathological features of primary colorectal cancer and classify it on histopathology and grading of tumor. Materials and Methods: This is retrospective, descriptive, analytical study carried out in the department of pathology at tertiary care hospital in Western Maharashtra. The study period was 5 years from May 2008 to April 2013. Result: A total of 217 cases of colorectal lesion were studied. Among these 73 cases (33.64%) were of non-neoplastic lesion, 19 cases (8.75%) were of benign, 125 cases (57.60%) were of colorectal malignancies. The rectum was commonest site of involvement by tumor. Maximum number of cases were observed in the age group of 61-70years of age (27.3%) with slight male predominance (M:F- 1.1:1). Bleeding per rectum was frequently seen clinical manifestation. Left sided colonic malignancy cases were common-89 cases / 125 (71.2%). The most common malignancy was adenocarcinoma which constitute 96 cases (76.8%) followed by mucinous adenocarcinoma 12 cases (9.6%), Signet cell adenocarcinoma 4 cases (3.2%). Among the 96 cases of adenocarcinoma grade I were 36 cases (37.89%), Grade II were 50 cases (52.08%), and grade III were 10 cases (10.52%). Conclusion: This study shows colorectal cancer is not an uncommon in this geographic region. The patients were presented at later age, left sided colonic malignancies were more. Bleeding per rectum is frequently seen clinical manifestation. Adenocarcinomas constitute (76.8%) as most common histological type with maximum cases in grade II (52.08%). This analysis suggests the need for patient awareness of this common cancer. Regular mass screening program to be implemented which will help for early detection and treatment of CRC
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