Adrenaline Intolerance in ASD Curing from Autoimmune Pathogens — Sebaceous Immunobiology in Autoimmune Pathogen
Keywords:
chromatophores, degeneration, immunology, ions, lipids, observational trial, oxidative stress, sebaceous immunobiology, sebumAbstract
The review is a summative of the clinical trials numbered NCT05711810 and NCT05839236 on ClinicalTrials.gov, with the sole participant's recovery from autoimmune pathogens who was also diagnosed as neurodivergent during the first interventional trial. The review seeks to bridge the literature gaps between psychiatry and the medical sciences on neurodiversity, focusing on immunobiology. It chooses the concept of adrenaline intolerance during the final phase of the recovery process to summarize the clinical evidence. The first part of the review synthesizes the key locations of autism spectrum disorder (ASD)'s neurological differences to neurotypical individuals. With the anatomic overview, the second part reviews the relevance to the immune system and implications in immune reflex. The third part examines the neuroatypical hormonic paths based on the ASD participant's data, whereby the final recovery process with hypolipidemic agent intervention posed a contradiction between the neuronal needs and autoimmune needs of the participant's internal conditions. The review predicts that the contradiction between clinical observation and medical literature offers a new window into the study of sebaceous immunobiology.
References
Zouboulis, C.C., Coenye, T., He, L., et al., Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations. Frontiers in Immunology, 2022. 13. DOI: 10.3389/fimmu.2022.1029818.
Lovászi, M., Szegedi, A., Zouboulis, C.C., et al., Sebaceous-immunobiology is orchestrated by sebum lipids. Dermato-Endocrinology, 2017. 9(1). DOI: 10.1080/19381980.2017.1375636.
Zouboulis, C.C., Epidermal growth factor receptor and the sebaceous gland. Experimental Dermatology, 2013. 22(11): p. 695-696. DOI: 10.1111/exd.12220.
Pachankis, Y.I., COVID-19 Vaccination Detoxification in LDL-C. 2023.
Pachankis, Y.I., Medicine-induced Cardiac Hemodialysis on COVID-19. 2023.
Whitehouse, A.J.O., Pennell, C.E., and Ronald, A., Prenatal Maternal Stress Associated with ADHD and Autistic Traits in early Childhood. Frontiers in Psychology, 2011. 1. DOI: 10.3389/fpsyg.2010.00223.
Parellada, M., Penzol, M.J., Pina, L., et al., The neurobiology of autism spectrum disorders. European Psychiatry, 2020. 29(1): p. 11-19. DOI: 10.1016/j.eurpsy.2013.02.005.
Salih, R.Q., Salih, G.A., Abdulla, B.A., et al., False-positive HIV in a patient with SARS-CoV-2 infection; a case report. Annals of Medicine and Surgery, 2021. 71. DOI: 10.1016/j.amsu.2021.103027.
Zhang, X.W. & Yap, Y.L., Structural similarity between HIV-1 gp41 and SARS-CoV S2 proteins suggests an analogous membrane fusion mechanism. Journal of Molecular Structure: THEOCHEM, 2004. 677(1): p. 73-76. DOI: 10.1016/j.theochem.2004.02.018.
Robinson, M.A., Nagurla, S.R., Noblitt, T.R., et al., Falsely positive fourth generation ADVIA Centaur® HIV Antigen/Antibody Combo assay in the presence of autoimmune hepatitis type I (AIH). IDCases, 2020. 21. DOI: 10.1016/j.idcr.2020.e00886.
Breit, S., Kupferberg, A., Rogler, G., et al., Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders. Frontiers in Psychiatry, 2018. 9. DOI: 10.3389/fpsyt.2018.00044.
Kox, M., van Eijk, L.T., Zwaag, J., et al., Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans. Proceedings of the National Academy of Sciences, 2014. 111(20): p. 7379-7384. DOI: 10.1073/pnas.1322174111.
Chu, A. & Wadhwa, R., Selective Serotonin Reuptake Inhibitors, in StatPearls. 2023: Treasure Island (FL). https://www.ncbi.nlm.nih.gov/pubmed/32119293.
Pappas, A., Epidermal surface lipids. Dermatoendocrinol, 2009. 1(2): p. 72-76. DOI: 10.4161/derm.1.2.7811.
Reyes, T.M., High-fat diet alters the dopamine and opioid systems: effects across development. Int J Obes Suppl, 2012. 2(Suppl 2): p. S25-28. DOI: 10.1038/ijosup.2012.18.
Waxenbaum, J.A., Reddy, V., and Bordoni, B., Anatomy, Head and Neck: Cervical Nerves, in StatPearls. 2023: Treasure Island (FL). https://www.ncbi.nlm.nih.gov/pubmed/30844163.
Castien, R. & De Hertogh, W., A Neuroscience Perspective of Physical Treatment of Headache and Neck Pain. Frontiers in Neurology, 2019. 10. DOI: 10.3389/fneur.2019.00276.
Ashina, M., Hansen, J.M., Do, T.P., et al., Migraine and the trigeminovascular system-40 years and counting. Lancet Neurol, 2019. 18(8): p. 795-804. DOI: 10.1016/S1474-4422(19)30185-1.
Pachankis, Y.I. Deidentified Data for Clinical Trial and Clinical Evidence [dataset]. Open Science Framework, 2023. DOI: 10.17605/OSF.IO/2MGJK.
Herr, N., Bode, C., and Duerschmied, D., The Effects of Serotonin in Immune Cells. Front Cardiovasc Med, 2017. 4: p. 48. DOI: 10.3389/fcvm.2017.00048.
Ragab, D., Salah Eldin, H., Taeimah, M., et al., The COVID-19 Cytokine Storm; What We Know So Far. Frontiers in Immunology, 2020. 11. DOI: 10.3389/fimmu.2020.01446.
Piérard-Franchimont, C., Quatresooz, P., and Piérard, G.E., Sebum Production, in Textbook of Aging Skin. 2010. p. 343-352. DOI: 10.1007/978-3-540-89656-2_33.
Spick, M., Longman, K., Frampas, C., et al., Changes to the sebum lipidome upon COVID-19 infection observed via rapid sampling from the skin. EClinicalMedicine, 2021. 33. DOI: 10.1016/j.eclinm.2021.100786.
Wang, D. & Hiesinger, P.R., The vesicular ATPase: A missing link between acidification and exocytosis. Journal of Cell Biology, 2013. 203(2): p. 171-173. DOI: 10.1083/jcb.201309130.
Glebov, O.O., Understanding SARS‐CoV‐2 endocytosis for COVID‐19 drug repurposing. The FEBS Journal, 2020. 287(17): p. 3664-3671. DOI: 10.1111/febs.15369.
Kreutzberger, A.J.B., Sanyal, A., Saminathan, A., et al., SARS-CoV-2 requires acidic pH to infect cells. Proceedings of the National Academy of Sciences, 2022. 119(38). DOI: 10.1073/pnas.2209514119.
Petersen, O.H., Gerasimenko, O.V., and Gerasimenko, J.V., Endocytic uptake of SARS-CoV-2: the critical roles of pH, Ca2+, and NAADP. Function, 2020. 1(1). DOI: 10.1093/function/zqaa003.
Pachankis, Y.I., Proton Paths of Cardiac Immune Reflex. Online Journal of Cardiology Research & Reports, 2023. 7(1). DOI: 10.33552/OJCRR.2023.06.000655.
Zhao, M., Luo, Z., He, H., et al., Decreased Low-Density Lipoprotein Cholesterol Level Indicates Poor Prognosis of Severe and Critical COVID-19 Patients: A Retrospective, Single-Center Study. Frontiers in Medicine, 2021. 8. DOI: 10.3389/fmed.2021.585851.
Hioki, T., Gholami, Y.H., McKelvey, K.J., et al., Overlooked potential of positrons in cancer therapy. Sci Rep, 2021. 11(1): p. 2475. DOI: 10.1038/s41598-021-81910-4.
Kitajima, Y., Ishii, T., Kohda, T., et al., Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis. Scientific Reports, 2019. 9(1). DOI: 10.1038/s41598-019-44981-y.
Logan, M.R., Odemuyiwa, S.O., and Moqbel, R., Understanding exocytosis in immune and inflammatory cells: The molecular basis of mediator secretion. Journal of Allergy and Clinical Immunology, 2003. 111(5): p. 923-932. DOI: 10.1016/s0091-6749(03)80114-8.
Slominski, A.T., Zmijewski, M.A., Plonka, P.M., et al., How UV Light Touches the Brain and Endocrine System Through Skin, and Why. Endocrinology, 2018. 159(5): p. 1992-2007. DOI: 10.1210/en.2017-03230.
Khan, N., Chen, X., and Geiger, J.D., Role of Endolysosomes in Severe Acute Respiratory Syndrome Coronavirus-2 Infection and Coronavirus Disease 2019 Pathogenesis: Implications for Potential Treatments. Frontiers in Pharmacology, 2020. 11. DOI: 10.3389/fphar.2020.595888.
Conrad, K.P., Might proton pump or sodium‐hydrogen exchanger inhibitors be of value to ameliorate SARs‐CoV‐2 pathophysiology? Physiological Reports, 2020. 8(24). DOI: 10.14814/phy2.14649.
Betari, N., Sahlholm, K., Morató, X., et al., Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole—In Vitro and In Vivo Investigations. Frontiers in Pharmacology, 2020. 11. DOI: 10.3389/fphar.2020.593416.
Pfeffer, C.M. & Singh, A.T.K., Apoptosis: A Target for Anticancer Therapy. Int J Mol Sci, 2018. 19(2). DOI: 10.3390/ijms19020448.
McCorry, L.K., Physiology of the autonomic nervous system. Am J Pharm Educ, 2007. 71(4): p. 78. DOI: 10.5688/aj710478.
Al-Zaid, F.S., Alhader, A.F.A., and Al-Ayadhi, L.Y., A potential role for the adrenal gland in autism. Sci Rep, 2021. 11(1): p. 17743. DOI: 10.1038/s41598-021-97266-8.
Bohm, M., Neuroendocrine regulators: Novel trends in sebaceous gland research with future perspectives for the treatment of acne and related disorders. Dermatoendocrinol, 2009. 1(3): p. 136-140. DOI: 10.4161/derm.1.3.9666.
Kienbaum, P., Thurauf, N., Michel, Martin C., et al., Profound Increase in Epinephrine Concentration in Plasma and Cardiovascular Stimulation after [micro sign]-Opioid Receptor Blockade in Opioid-addicted Patients during Barbiturate-induced Anesthesia for Acute Detoxification Anesthesiology, 1998. 88(5): p. 1154-1161. DOI: 10.1097/00000542-199805000-00004.
Troutman, G.S., Salamon, J., Scharf, M., et al., Cold at the Core: Osborn Waves in Neurosarcoidosis-Induced Central Hypothermia. Case Rep Cardiol, 2019. 2019: p. 5845839. DOI: 10.1155/2019/5845839.
Pachankis, Y.I., Theoretical Strategies in SARS-CoV-2 Human Host Treatment. Journal of Clinical and Medical Images, 2023. 6(28).
Moretti, J. & Blander, J.M., Cell-autonomous stress responses in innate immunity. J Leukoc Biol, 2017. 101(1): p. 77-86. DOI: 10.1189/jlb.2MR0416-201R.
Gorry, P.R., Francella, N., Lewin, S.R., et al., HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies. J Leukoc Biol, 2014. 95(1): p. 71-81. DOI: 10.1189/jlb.0713368.
Chen, Y. & Lyga, J., Brain-skin connection: stress, inflammation and skin aging. Inflamm Allergy Drug Targets, 2014. 13(3): p. 177-190. DOI: 10.2174/1871528113666140522104422.
Li, W., Yang, S., Kim, S.O., et al., Lipopolysaccharide-Induced Profiles of Cytokine, Chemokine, and Growth Factors Produced by Human Decidual Cells Are Altered by Lactobacillus rhamnosus GR-1 Supernatant. Reprod Sci, 2014. 21(7): p. 939-947. DOI: 10.1177/1933719113519171.
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