Metabolic Profile of patients with acute Myocardial Infarction
Keywords:
Acute myocardial infarction, Free fatty acids, Lipid profile, Blood glucoseAbstract
Background: Acute myocardial infarction (AMI) is a multifactorial disease characterized by profound cardiac metabolic changes. Serum FFA is elevated dramatically during and following AMI. Recently some researchers noted utility of serum FFA as a predictor of complications particularly arrhythmias in patients of AMI. Hence we included estimation of serum FFA along with blood glucose and lipid profile in our diagnosed cases of AMI. The aim of the present study was to characterize demographic features, anthropometric and glucometabolic profile of patients of AMI and compare with controls. Material and methods: A total of 50 diagnosed patients of AMI (chest pain, ST elevation, elevated CK-MB values and Troponin T values within 12 hours of onset of pain) were included in the present case control study. Detail clinical, personal history, past medical history, demographic and anthropometric data recorded. To assess metabolic profile, blood glucose, lipid profile and FFA were estimated. Results: Cases from AMI group had mean BMI 22.6+/- 2.2 Kg/m2 and waist circumference 83.2+/- 4.6 cm. We observed significant hyperglycemia, hypercholesterolemia, hypertriglyceridemia and raised LDL (mean- 213+/-54 Vs 84+/-13, 220+/-42 Vs 142+/-11, 356+/-102 Vs 112+/-43, and 165 +/- 23 Vs 102+/-13 respectively p<0.001) in cases compared to controls. Serum FFA elevated significantly (mean- 3.2mmol/l +/-0.9 Vs 0.8mmol/l+/-0.3, p<0.001) with significantly decreased HDL (mean- 31+/-5.6 Vs 54+/-10, p<0.05) levels in comparison with control. Conclusion: Present study reveals that patients of AMI without previous T2DM, dyslipedemia or other known cardiac risk factors have raised FFA with altered atherogenic lipoprotein pattern.
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