Chronic nonspecific musculoskeletal pain in adults with special reference to serum uric acid levels
Introduction: Increased serum uric acid levels have been found to be variably associated with chronic nonspecific musculoskeletal pain in different subgroups of population. The present study is aimed at knowing the association of increased serum uric acid levels in adult population with chronic nonspecific musculoskeletal pain. The primary outcome measure was to know the levels of serum uric acid levels in patients with chronic nonspecific musculoskeletal pain and, the secondary outcome measure was to know the effect of Hypouricemic agents Febuoxastat in patients with hyperuricemia.
Methods: One hundred and twenty five (n=125) adult patients (M: F-63:62) having chronic nonspecific musculoskeletal pain of ≥ 6 weeks duration were included in the study and, their serum uric acid levels were estimated. An eleven points (0-10) Numerical Rating Scale (NRS) was used to assess the level of chronic musculoskeletal pain in the study participants. Patients with hyperuricemia were given oral Hypouricemic drug febuoxastat. The study was conducted for period of one year.
Results: Serum uric acid levels were raised in a significant proportion (p value ˂0.0001) of patients (70.4%) with chronic nonspecific musculoskeletal pain. Mean serum uric acid level was 8.3mg/dl in 70.4% (n=88) patients and 5.6 mg/dl in 20 %( n=25) patients. Mean serum uric acid level was below 2.0mg/dl (1.85±0.10mg/dl) in the remaining 9.6% (n=12) patients. Among the 88 patients having higher mean serum uric acid levels 39.2% (n=49) were female and 31.2 %( n=39) were male patients.
Conclusion: Increased serum uric acid levels have an important role in the development and pathogenesis of chronic non specific musculoskeletal pain in adults. Both increased and decreased serum uric acid levels can cause symptomatic chronic nonspecific musculoskeletal pain However, the exact mechanisms linking hypouricemia to chronic musculoskeletal pain need further evaluation.
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