Antimicrobial activity of Maha Megarajanga thailam (MMRT) against Staphylococcus aureus and Methicillin Resistant Staphyloccus aureus (MRSA)
Keywords:
Antimicrobial resistance, MMRT(Maha Megarajanga Thailam), MRSA, Agar well diffusion, Broth dilutionAbstract
Staphylococcus aureus is primarily responsible for the persistent infections in chronic wounds. The overall prevalence of MRSA was 37% from 2015 to 2019. Based on the results of a meta-analysis the zone wise pooled prevalence of MRSA was found to be 41% , 43% , 33% , 34%, 36% and 40% for north, east, west, south, central, and northeast region-zones, respectively. There is uniform reporting of prevalence rate in all zones of India. Antimicrobial resistance (AMR) is one of the most serious global public health threats in this century. World Health Organization has insisted that MRSA is one of the high priority multidrug-resistant organism. Maha Megarajanga Thailam mentioned in the text Theraiyar Taila Varga Surukkam is an unique preparation used externally as well as internally. It has castor oil as base with more than 180 plant parts and minerals as ingredients. It has got unique therapeutic values against skin lacerations, burns, contusions, and diabetic wounds. Vaidyar Sachidananda Swamy has prepared this unique preparation for the past 40 years and has implemented it clinically. The agar well diffusion assay and broth dilution assays were used to determine the antibacterial activity of MMRT. The former is considered to be the gold standard of susceptibility testing which permits detection of contamination and microbial heterogeneity readily whereas broth dilution enables the reproducibility and economy of reagents. The results prove that MMRT is potent against Staphylococcus aureus and MRSA. It inhibits bacterial growth and has been proven to be effective in management of diabetic wounds and skin infections.
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